Association between GSTT1 and GSTM1 Null Polymorphisms with Pre-Malignant Oral Lesions in North Indian Population

Abstract

The objective of this investigation is to identify the relationship of GSTT1 and GSTM1 gene polymorphisms with risk of cancer in distinct population in North India with histopathological confirmed oral pre-malignant lesions. A range of parameters such as gender, age, tobacco habit, alcohol consumption and stages of pre-malignant were taken into consideration. Blood samples of 34 histopathological confirmed oral pre-malignant cases, were collected and analyzed for GSTT1 and GSTM1 polymorphisms by PCR method. Thus, the polymorphism of GSTM1 and GSTT1 gene involved may results in the differences in enzymatic activity possibly favoring mechanisms that increase the susceptibility to cancer. Hence, out of 100% pre- malignant population, 72.73% is more susceptible to cancer in case of GSTM1. While in the GSTT1 out of 100% pre- malignant population, 54.55% population is more susceptible to cancer. This study conclude that since the polymorphic genotypes were more in tests samples than the null genotypes, it may be associated with an increased risk of cancer from pre- malignant lesions of oral cancer.