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An Improved One-pot Method for the Synthesis of 1,5-Disubstituted Tetrazoles from Secondary amides using Titanium Tetrachloride (TiCl4)
Abstract
A novel protocol for the synthesis of 1,5-disubstituted tetrazoles from secondary amides has been developed using TiCl4 as a catalyst for first time. In the present protocol, the use of TiCl4 enhances the reactivity of sodium azide towards secondary amides. This methodology may be used efficiently for the synthesis of variety of 1,5-disubstituted tetrazoles.
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This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. This article can be used for non-commercial purposes. Mentioning of the publication source is mandatory while referring this article in any future works.
