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Considerable Recovery Effect Of EPL And Ashwagandha On The Weight Of Dams And Foetal Weight In Swiss Albino Mice Due To Intoxication Of Mercuric Chloride

Vishwas Tiwari
DOI: http://dx.doi.org/10.21013/jas.v5.n1.p6
Abstract

Investigations were furnished on the toxic effect of mercuric chloride in foetal weights and weight of dam in mice with remarkable recovery effect of Withania somnifera (Ashwagandha) and Essentiale phospholipids (EPL) were observed. Withania somnifera is popularly known as Indian Ginseng and its withanoid content improves the greater gain in body weight, whereas dilinoleoylphosphatidylcholine content of EPL revealed high affinity with lipid contents of blood which consequently increased adipose tissues of body.

 The animals were treated with 0.5 ppm aqueous mercuric chloride for a period of 7, 14 and 21 days. For the recovery 175 mg of EPL and 35 mg of ashwagandha were administered to mice (already treated with HgCl2) for a period of 7, 14 and 21 days. Daily treatment of HgCl2 for 7, 14 and 21 days decreased weight of foetuses and dams. Simultaneous administration of EPL and ashwagandha significantly recovered the weight of foetuses and dams. It appears that the protective effects of EPL and ashwagandha against HgCl2 induced weight alteration is mediated through antioxidative action of EPL and ashwagandha. 

Keywords
Dams, Foetus, Essentiale Phospholipids, Withania somnifera, Indian Ginseng
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