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SYNTHESIS OF 2-[SUBSTITUTED-2,4-DITHIABIURETO]-11-(PIPERAZIN-1-YL) DIBENZO [b,f][1,4] OXAZEPINES

D. T. Tayade, P. R. Kale
Abstract

Recently in this laboratory convenient method for synthesis of 2-[substituted-2,4-dithiabiureto]-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepines [VB(a-h)] was developed.  The interactions of 2-thiocarbamido-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine [IIIB(a)] with various isothiocyanates (IVa-h) in 50% acetone-ethanol medium were carried out on water bath to synthesized [VB(a-h)] respectively. The structures of synthesized compounds were justified on the basis of chemical characteristics, elemental analysis and spectral studies.

Keywords
Various isothiocyanate, 2-[substituted-2,4-dithiabiureto]-11-(piperazin-1-yl) dibenzo [b,f][1,4]oxazepines and 50% acetone-ethanol
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